Na channel regulation by Ca/calmodulin and Ca/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes
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چکیده
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منابع مشابه
Calcium-dependent regulation of voltage-gated sodium channels in cardiac myocytes: just the beginning?
This editorial refers to 'Na + channel regulation by Ca 2+ /calmodulin and Ca 2+ /calmodulin-depndent protein kinase II in guinea-pig ventricular myocytes' by T.
متن کاملRegulation of a voltage-sensitive release mechanism by Ca-calmodulin-dependent kinase in cardiac myocytes
Zhu, Jiequan, and Gregory R. Ferrier. Regulation of a voltage-sensitive release mechanism by Ca-calmodulin-dependent kinase in cardiac myocytes. Am J Physiol Heart Circ Physiol 279: H2104–H2115, 2000.—A role for Ca-calmodulin-dependent kinase (CamK) in regulation of the voltagesensitive release mechanism (VSRM) was investigated in guinea pig ventricular myocytes. Voltage clamp was used to separ...
متن کاملRegulation of a voltage-sensitive release mechanism by Ca(2+)-calmodulin-dependent kinase in cardiac myocytes.
A role for Ca(2+)-calmodulin-dependent kinase (CamK) in regulation of the voltage-sensitive release mechanism (VSRM) was investigated in guinea pig ventricular myocytes. Voltage clamp was used to separate the VSRM from Ca(2+)-induced Ca(2+) release (CICR). VSRM contractions and Ca(2+) transients were absent in cells dialyzed with standard pipette solution but present when 2-5 microM calmodulin ...
متن کاملNa+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes.
AIMS Calmodulin (CaM) regulates Na+ channel gating through binding to an IQ-like motif in the C-terminus. Ca2+/CaM-dependent protein kinase II (CaMKII) regulates Ca2+ handling, and chronic overactivity of CaMKII is associated with left ventricular hypertrophy and dysfunction and lethal arrhythmias. However, the acute effects of Ca2+/CaM and CaMKII on cardiac Na+ channels are not fully understoo...
متن کاملCalmodulin reverses rundown of L-type Ca(2+) channels in guinea pig ventricular myocytes.
Calmodulin (CaM) is implicated in regulation of Ca(2+) channels as a Ca(2+) sensor. The effect of CaM on rundown of L-type Ca(2+) channels in inside-out patch form was investigated in guinea pig ventricular myocytes. Ca(2+) channel activity disappeared within 1-3 min and did not reappear when the patch was excised and exposed to an artificial intracellular solution. However, application of CaM ...
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تاریخ انتشار 2009